Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis
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منابع مشابه
Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis
Rapid neurotransmitter release depends on the ability to arrest the SNAP receptor (SNARE)-dependent exocytosis pathway at an intermediate "cocked" state, from which fusion can be triggered by Ca(2+). It is not clear whether this state includes assembly of synaptobrevin (the vesicle membrane SNARE) to the syntaxin-SNAP-25 (target membrane SNAREs) acceptor complex or whether the reaction is arres...
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متن کاملCommentary SNAREs and regulated vesicle exocytosis
Synaptic vesicle exocytosis—the basis for neurotransmitter release at nerve terminals—is at the heart of nervous system functioning. The molecular analysis of this special form of exocytosis was recently greatly stimulated by the finding that the key molecules in various intracellular vesicular transport steps, including neurotransmitter release, are conserved from yeast to man (1–3). Prompted ...
متن کاملSynaptic vesicle proteins and regulated exocytosis.
The recent identification of novel proteins associated with the membranes of synaptic vesicles has ignited the field of molecular neurobiology to probe the function of these molecules. Evidence is mounting that the vesicle proteins vamp (synaptobrevin), rab3A, synaptophysin, synaptotagmin (p65) and SV2 play an important role in regulated exocytosis, by regulating neurotransmitter uptake, vesicl...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2010
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.200907018